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Publications

Type 1 Diabetes

Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody 

Vβ13 as a Therapeutic Target and Biomarker.

Zhijun Liu, Laura Cort, Ryan Eberwine, Thomas Herrmann, Jean H. Leif, Dale L. Greiner,

Barak Yahalom, Elizabeth P. Blankenhorn, and John P. Mordes

Development of Standardized Insulin Treatment Protocols for Spontaneous Rodent Models of Type 1 Diabetes.

Christian W Grant, Shane K Duclos, Catherine M Moran-Paul, Barak Yahalom, Rebecca S Tirabassi, Guillermo Arreaza-Rubin, Lisa M Spain, and Dennis L Guberski

LEW.1WR1 Rats Develop Autoimmune Diabetes

Spontaneously and in Response to Environmental

Perturbation

John P. Mordes, Dennis L. Guberski, Jean H. Leif, Bruce A. Woda, Joan F. Flanagan, Dale L. Greiner, Edward H. Kislauskis, and Rebecca S. Tirabassi

Type 2 Diabetes and Metabolic Syndrome

The C57BL/6NCrl-lb Mouse: A New Model for Metabolic Syndrome

Dwight R. Owens, Richard G. Peterson, Wu-Kuang Yeh, Yiyun Wang, Kathleen R. Pritchett- Corning1, Bruce Elder, Charles B. Clifford and Joan Flanagan

Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes.

Leshem O, Reuveni H, Wexler I, Ben Sasson R, Yahalom B, Laster M, Raz I, Ben Sasson S, Shafrir E, Ziv E

The BBZDR/Wor Rat Model for Investigating the Complications of Type 2 Diabetes Mellitus

Rebecca S. Tirabassi, Joan F. Flanagan, Tiangen Wu, Edward H. Kislauskis, Paul J. Birckbichler, and Dennis L. Guberski

Gene Therapy

Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy. Molecular Therapy.

DeRosa F, Smith L, Shen Y, Huang Y, Pan J, Xie H, Yahalom B, Heartlein MW

Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation

Amita Vaidya, Dipen Parande, Nikita Khadse, Natalia Vargas-Montoya, Vikram Agarwal, Christian Ortiz, Gordon Ellis, Neha Kaushal, Ashish Sarode, Shrirang Karve, and Frank DeRosa

Therapeutic Efficacy in a Hemophilia B Model Using a Biosynthetic mRNA Liver Depot System. Gene Therapy.

DeRosa F, Guild B, Karve S, Smith L, Love K, Dorkin JR, Kauffman KJ, Zhang J, Yahalom B, Anderson DG, Heartlein MW

Mechanistic model for improved performance of
mRNA–LNPs formulated under turbulent
mixing conditions

Richard Mosesso, Katie Randall, Amita Vaidya, Jackie Tang, Trent Northen, Aure´lie Deliot, Mengwei Sun, Rebecca Goldman, Adam Lyons, Lingyun Liu, Shrirang Karve and Frank DeRosa

Understanding structure activity relationships of Good HEPES lipids for lipid nanoparticle mRNA vaccine applications

Rebecca L. Goldman, Namratha Turuvekere Vittala Murthy, Trent P. Northen, Anuranjani Balakrishnan, Sudha Chivukula, Hillary Danz, Timothy Tibbitts, Anusha Dias, Jorel Vargas, Dustin Cooper, Hardip Gopani, Angela Beaulieu, Kirill V. Kalnin, Timothy Plitnik, Saswata Karmakar, Ramesh Dasari, Ryan Landis, Shrirang Karve, Frank DeRosa

Anesthesia / Analgesia

Antinociceptive Effect of Vapocoolant Medium Stream Spray on Hotplate Latencyin Rat Pups

Navil F. Sethna, MD, Brenden Fish, BS, Barak Yahalom, DVM, Birgitta Schmidt, MD, David Zurakowski, MS, PhD

Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia.

Charles B. Berde, Umeshkumar Athiraman, Barak Yahalom, David Zurakowski, Gabriel Corfas  and Christina Bognet 

Spinal anesthesia in Infant Rats: Development of a Model, Preliminary Observations, and Assessment of Neurologic Outcomes.

Yahalom B, Athiraman UK, Soriano S, Zurakowski D, Corfas G, Carpino E, Berde CB

Gene Regulation

Structural analysis of the yeast SWI/SNF chromatin remodeling complex

Corey L. Smith , Rachel Horowitz-Scherer , Joan F. Flanagan, Christopher L. Woodcock

and Craig L. Peterson1

A role for the yeast SWI/SNF complex in DNA replication

Joan F. Flanagan and Craig L. Peterson

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