Alpha specializes in early preclinical research, with a focus on in vivo PK-PD lead optimization, feasibility proof-of-concept, efficacy and iterative preclinical testing. Alpha is passionate about our role in providing a personalized interface with our clients. We take pride in our core values of humane care of animals, and delivering the highest quality of research, while providing our in vivo services in a timely manner at an affordable cost for our research community.

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In support of our in vivo contract research expertise, we offer support though the following services:

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• Compound Formulation Support

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• Test material preparation of study related induction reagents, vehicles, and test articles.

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IVIS Imaging 

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Our state of the art Spectrum IVIS imager is capable of imaging bioluminescence and fluorescence in live whole-body images or via ex vivo tissue imaging. 

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Colony Management 

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Our staff is highly trained and skilled in rodent breeding and reproduction to meet our client’s needs for custom colony management solutions. 

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• Equipped with Innovive racks for housing of colonies 

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• Appoint project manager for data collection and colony management

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• Sound development of husbandry and supportive approaches for improving breeding strategies and efficiencies

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Surgical Services

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Our team is specially trained to perform surgeries in small and large animal species, using aseptic and sterile techniques that prevent operative complications permitting a smoother surgical recovery.

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• USDA compliant surgical suite

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• Staff DVM proficient in surgical procedures

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• Surgical models for Specialized ROAs:

  • Alzet continuous subcutaneous administration

  • Intracerebroventricular (ICV)

 

In Vitro Laboratory Services

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• Development, performance and troubleshooting various biomarkers in vitro assays, including cytokine and molecular ELISA assays

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• Complete blood count (CBC) differentials

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• Serum chemistry analyses

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• Primary cell collections, isolations and preparations (fresh or frozen cell suspensions and cell lysates) including hepatocytes, non-parenchymal cells and microsomes from liver, lung tissue, and  PBMCs.

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• Magnetic bead sorting for various immune cell types

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• Flow Cytometry

  • Performance and development of multicolor flow cytometry on various cell types including virus and T-cell stimulation assays, and T and B cell immuno-phenotyping

  • T-cell and B-cell flow cytometry assays, viral stimulation flow cytometry assays

  • Analysis of flow data using FlowJo software

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• Cell culture: culturing of primary and immortal cell lines

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• Histology

  • Immunohistochemistry

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