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Pharmacokinetic (PK) / Pharmacodynamic (PD)

Alpha understands the critical importance of PK/PD - the cornerstone of pharmacology - for pharmacotherapy development. We offer well-executed PK/PD studies in a timely  manner to allow our clients to test and evaluate the biochemical and physiologic effects of their compounds using a variety of animal models.

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  • Primarily focused on rodents studies, with the capability to conduct studies in most common laboratory research species

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  • Proficient at routine routes of administration (IV, per os, SC, IP, IM, ID, topical, rectal)

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  • Specialized methods of administration including but not limited to hydrodynamic IV, intravitreal injection (IVt), intra articular injection (IA), Alzet continuous subcutaneous administration, intrathecal injection (ITh), intratracheal administration (ITr), intracerebroventricular (ICV), nebulizer administration, intrasplenic and portal vein injections

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  • Routine and specialized sample collection (blood, urine, feces, cerebral spinal fluid (CSF), bile)

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  • In-life Imaging (IVIS: bioluminescence and fluorescence) 

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PK/PD

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Gene Therapy

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Autoimmune Disease

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Metabolic Diseases 

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Inflammation/ Fibrosis Models

Tumor Models

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